Certain toxic compounds (T) such as, for example, compounds based upon diphtheria
toxin, ricin toxin, pseudomonas exotoxin, -amanitin, pokeweed antiviral
protein (PAP), ribosome inhibiting proteins, especially the ribosome inhibiting
proteins of barley, wheat, corn, rye, gelonin and abrin, as well as certain cytotoxic
chemicals such as, for example, melphalan and daunomycin can be conjugated to certain
analogs of gonadotropin-releasing hormone to form a class of compounds which, when
injected into an animal, destroy the gonadotrophs of the animal's anterior pituitary
gland. Hence such compounds may be used to sterilize such animals and/or to treat
certain sex hormone related diseases.
