A particle-enhanced assay for determining an analyte in a test sample in which
an additive for reducing non-specific particle aggregation is added in an amount
to substantially reduce non-specific aggregation. The additive is selected form
the group consisting of triethanolamine, trimethanolamine, N-butyldiethanolamine,
3-dimethylamino-2-methylpropyl chloride, N,N-dimethylglycine, N,N-dimethylguanidine,
N,N-dimethylglycine ethyl ester, 3-dimethylaminopropionitrile, and N,N-dietylacetamide.
