The present invention provides a conjugate wherein GP (glycoprotein) Ib and a
lipid are bonded via polyalkylene oxide. The present invention also provides a
complex (GPIb lipid complex) containing this conjugate and a free lipid. The GPIb
lipid complex is expected to have a potential for practical application in a wide
range, as a platelet substitute, a pharmaceutical agent for the prophylaxis or
treatment of angiopathy, vascular damage and thrombosis, a diagnostic for vWF deficiency
and the like, a biological or medical reagent, a reagent for screening platelet
aggregation suppressant or antithrombosis, and the like. The GPIb lipid complex
of the present invention is also useful as a diagnostic for finding the location
of vascular lesion or thrombus formation, or a therapeutic agent thereof. Moreover,
the GPIb lipid complex of the present invention is also superior in retention property
in blood, which enables continuous expression of a pharmacological action. The
conjugate of the present invention is highly utilizable as an active ingredient
of the GPIb lipid complex of the present invention.
