A method and system are provided for determining a condition of a selected region
of epithelial tissue. At least two current-passing electrodes are located in contact
with a first surface of the selected region of the tissue. A plurality of measuring
electrodes are located in contact with the first surface of the selected region
of tissue as well. Electropotential and impedance are measured at one or more locations.
An agent may be introduced into the region of tissue to enhance electrophysiological
characteristics. The condition of the tissue is determined based on the electropotential
and impedance profile at different depths of the epithelium, tissue, or organ,
together with an estimate of the functional changes in the epithelium due to altered
ion transport and electrophysiological properties of the tissue.
