8-arylquinolines of formula (I) wherein the aryl group at the 8-position
contains a meta two atom bridge to an optionally substituted phenyl or pyridyl
group, are PDE4 inhibitors useful to treat asthma, chronic bronchitis, chronic
obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic
rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, and other diseases.
R1-R7 and Ar are as in claim 1.
##STR1##
