A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl
substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically
effective amount and preferably further comprises one or more pharmaceutically
active drugs such as an anti-inflammatory glucocorticosteroid, a sympathomimetic
amine decongestant, an anti-histamine, a local anesthetic, menthol or a menthol
analog, and mixtures thereof. The cold receptor agonist may be represented by the
general formula 1-[R1-phenyl]-4-[R2-phenyl]-1,2,3,6-tetrahydropyrimidine-2-one
wherein: R1 is -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl;
and R2 is -nitro, -chloro, -fluoro, -alkyl, -trifluoromethyl. Therapeutic compositions
of the invention elicit long-lasting cooling or soothing, particularly when formulated
for delivery to suppress the sensations of itch and pain, such as for delivery
to inflamed skin, to the mucous membranes of the anogenital areas, and to the enteric mucosa.
