Compounds having the formula (I),
##STR1##
wherein R3 is selected from H, OH and NH2; R30
is selected from O and S; W is -C(O)-, -S(O)-,
or -S(O)2-; or W may be -CH2- if X is -C(O)-; X is
selected from -CH2-, -N(R4)-, and -O-, except that when W
is -CH2-, X is -C(O)-; Y is a bond or -C(R40)(R45)-;
Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl,
aryl, heteroaryl, or heterocyclyl; and X1, X2, X3,
X4, X5, X6, X7, X8, X9,
X10 and X11 are selected such a tricyclic heteroaryl ring
system is formed as further defined in the specification.
