Method for enhancing in a mammalian cell the activity of an enzyme associated
with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase
in an amount effective to enhance the activity of the enzyme. Preferred compounds
for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl
derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine
compoiunds are effective to enhance glucocerebrosidase activity.
