IL-1/TNF--activated kinase (ITAK), and methods of making and using the same

Purified and isolated IL-1/TNF--activated kinase (ITAK), nucleic acids encoding ITAK, processes for production of recombinant forms of ITAK, pharmaceutical compositions containing ITAK, and use of ITAK in therapies and in various assays, including assays to detect antagonists and agonists of ITAK are provided.