Human antibodies, preferably recombinant human antibodies, that specifically
bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have
high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An
antibody of the invention can be a full-length antibody or an antigen-binding portion
thereof. The antibodies, or antibody portions, of the invention are useful for
detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering
from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors
and host cells for expressing the recombinant human antibodies of the invention,
and methods of synthesizing the recombinant human antibodies, are also encompassed
by the invention.
