A sulfonamide compound of the formula (I):
wherein R1 is alky, alkenyl, alkynyl and the like; A is an optionally
substitutedheteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyland
2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and
R2 is optionally substituted aryl, substituted biphenylyl and the like,
a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide
compound is effective for the diseases treatable based on their blood sugar level-depressing
activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing
activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing
activity, and antiallergic activity.
