Methods and apparatus for qualitative and quantitative proteome analysis
are provided. The methods and apparatus allow for the isolation of a subset of
peptides out of complex mixtures of peptides. The isolation is based on a specific
chemical and/or enzymatic alteration of one or more types of peptides. This alteration
modifies the biophysical, chemical or any other biochemical property of the affected
types of peptides (e.g., net electrical charge and/or hydrophobicity) in such way
that the altered peptides can be separated from the unaltered peptides.
