The present invention is directed to novel methods for inhibiting
angiogenesis and treating tumors and cancer by targeting tropomyosin
(Tpm) expressed on the surface of endothelial cells and/or tumor cells,
to Tpm polypeptides and peptides, as well as variants and derivatives
thereof that bind inhibitors of angiogenesis, and to anti-Tpm antibodies
that block or stimulate angiogenesis. Cyclic peptides that bind to the D5
subunit of HK.sub.a and inhibit angiogenesis are also included. Method
for screening test compounds as candidate antiangiogenic molecule that
binds to Tpm are disclosed, as are affinity ligands comprising the
proteins, peptides, variants and derivatives of the invention.
