The present invention relates to isolated nucleic acid molecules
conferring on mammalian carcinoma cells an ability to undergo cell
migration. Recombinant DNA expression systems and host cells containing
the subject nucleic acid molecule, as well as antisense oligonucleotides,
are also described. Also disclosed are methods of inhibiting expresssion
of the subject nucleic acid molecule, inhibiting production of the
encoded protein or polypeptide, inhibiting metastasis of a carcinoma cell
in a subject (including in humans), inhibiting migration of carcinoma
cell in a subject, detecting the presence of a migrating carcinoma cell
in a sample of a subject's tissue or body fluids, and inhibiting the
migration of a placental cell into the blood stream of a female mammal.
