A compound of the formulae (I) or (II):
##STR1##
wherein:
- Y is a moiety selected from NR or (CH2)n;
- wherein R is hydrogen or (C1-C6) lower alkyl,
- and n is 1;
##STR2##
represents:
- (1) a phenyl ring optionally substituted with one or two substituents
selected, independently, from the group comprising hydrogen, (C1-C6)
lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6)
lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, CONH2,
CONH[(C1-C6) lower alkyl], CON[(C1-C6)
lower alkyl]2; or
- (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one
nitrogen atom, optionally substituted by (C1-C6) lower alkyl,
halogen or (C1-C6) lower alkoxy;
##STR3##
represents:
- (1) a phenyl ring optionally substituted with one or two substituents
selected, independently, from the group comprising hydrogen, (C1-C6)
lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6)
lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy,
CONH2, CONH[(C1-C6) lower alkyl],
CON[(C1-C6) lower alkyl]2; or
- (2) a 5-membered aromatic (unsaturated) heterocyclic ring having one
nitrogen atom, optionally substituted by (C1-C6) lower alkyl,
(C1-C6) lower alkoxy, or halogen; or
- (3) a 6-membered aromatic (unsaturated) heterocyclic ring having one
nitrogen atom, optionally substituted by (C1-C6) lower alkyl,
halogen, or (C1-C6) lower alkoxy;
##STR4##
represents a 5-membered aromatic (unsaturated) heterocyclic ring having
one sulfur atom, optionally substituted by (C1-C6) lower
alkyl, halogen, or (C1-C6) lower alkoxy;
- R1 is a moiety of the formula
##STR5##
and R2, R3, R7, R8 and R9 are,
independently, selected from a group consisting of hydrogen, (C1-C3)
lower alkyl, OCH3, halogen, CF3, SCH3,
OCF3, SCF3, or CN;
or a pharmaceutically acceptable salt, or pro-drug form thereof.
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