This invention provides compounds having drug and bio-affecting properties,
their pharmaceutical compositions and method of use. In particular, the invention
is concerned with sulfonylureido piperazine derivatives of Formula I. These compounds
possess unique antiviral activity, whether used alone or in combination with other
antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly,
the present invention relates to the treatment of HIV and AIDS.
##STR1##
wherein:
- Z is
##STR2##
- Q is selected from the group consisting of:
##STR3##
- W is
##STR4##
- represents a carbon-carbon bond or does not exist; and
- A is NR13R14.
