The invention provides methods, therapeutics and kits for treating and preventing
diseases or conditions associated with excessive lipolysis, in particular TNF-
induced lipolysis, and/or excessive free fatty acid levels. Exemplary conditions
include insulin-resistance, diabetes, in particular NIDDM, obesity, glucose intolerance,
hyperinsulinemia, polycystic ovary syndrome, and coronary artery disease. In a
preferred embodiment, the method includes administering to a subject in need a
pharmaceutically effective amount of an inhibitor of the JNK signal transduction
pathway and/or an inhibitor of the MAPK/ERK signal transduction pathway.
