The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines,
and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention
are dual acting molecules having both leukotriene inhibition properties as well
as antihistaminergic properties. The compounds of the invention are useful for
treating conditions in which there is likely to be a histamine and/or leukotriene
component. These conditions include preferably asthma, seasonal and perennial allergic
rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis,
urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease,
chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also
provided are methods of treating asthma and rhinitis by administering an effective
asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
