The present invention relates to the use of therapeutic compounds in the modification
of T-cells, T-cell-antigen presenting cell (APC) interactions and the interaction
between pathogenic organism and immunocompetent cells of a host. In particular,
it relates to the use of these compounds in the modulation of the interaction between
Notch proteins and their ligands and to the use of such compounds in the therapy
of conditions such as graft rejection, autoimmunity, allergy, asthma and infectious diseases.
