Medical devices incorporating deuterated rapamycin for controlled delivery thereof

Deuterated rapamycin can be controllably introduced target locations within the patient's body by using an implantable medical device having a structure incorporated with a therapeutic agent comprising a deuterated rapamycin. Representative deuterated rapamycins include epi-7-deuteromthyl rapamycin, 7,43-d₆ rapamycin, 7-deuteromethyl rapamycin and 31,42-d₂-rapamycin and isomers thereof, and mixtures thereof. The deuterated rapamycin can also be glycosylated.