Myeloid cell promoter and constructs containing same

   
   

The present invention provides novel myeloid cell specific promoters, and cis-acting elements that influence the activity of a myeloid cell specific promoters, as well as promoter-heterologous gene constructs and transfected myeloid cells which include the novel promoters and/or the novel cis-acting elements. The present invention also provides a method of transfecting myeloid cells and a method of producing a selected product within the transfected cells. The invention also includes a method for identifying factors that can regulate myeloid cell specific transcription.

De onderhavige uitvinding verschaft nieuwe myeloid cel-specifieke promotors, en GOS-HANDELENDE elementen die de activiteit van myeloid cel-specifieke promotors beïnvloeden, evenals promotor-heterologe genconcepten en transfected myeloid cellen die de nieuwe promotors en/of de nieuwe GOS-HANDELENDE elementen omvatten. De onderhavige uitvinding verstrekt ook een methode om myeloid cellen transfecting en een methode om een geselecteerd product binnen te produceren transfected cellen. De uitvinding omvat ook een methode om factoren te identificeren die myeloid cel-specifieke transcriptie kunnen regelen.

 
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