Asymmetric ligands useful for transition metal catalyzed bond forming reactions

   
   

Ligands useful for transition metal catalyzed bond forming reactions are provided with a metal binding portion having at least one metal binding moiety ##STR1## wherein Ar and Ar' each is an aryl or a heteroaryl. These ligands may be prepared by providing an aromatic carboxylic acid having a diarylphosphino or diheteroarylphosphino substituent on the aromatic ring, and forming an ester or an amide derivative of the carboxylic acid by coupling with a chiral diol or a chiral diamine. The ligands facilitate, for example, flexible strategies for enantiocontrolled construction of five membered carbocyclic rings with varying substitution patterns and high enantioselectivity.

Ligands útil para a ligação catalyzed metal da transição que dá forma a reações é fornecido com uma parcela obrigatória do metal que tem ao menos um ## obrigatório do ## STR1 do moiety do metal wherein Ar e Ar ' cada um são um arilo ou um heteroaryl. Estes ligands podem ser preparados fornecendo um ácido carboxylic aromatic que tem um substituent do diarylphosphino ou do diheteroarylphosphino no anel aromatic, e dando forma a um ester ou a um derivative do amido do ácido carboxylic acoplando com um diol chiral ou um diamine chiral. Os ligands facilitam, para o exemplo, estratégias flexíveis para enantiocontrolled uma construção de cinco membered anéis carbocyclic com testes padrões variando da substituição e o enantioselectivity elevado.

 
Web www.patentalert.com

< Multipath calibration in GPS pseudorange measurements

< Timing and frequency synchronization of OFDM signals

> Method for inharmonic tone generation using a coupled mode digital filter

> Prevention and treatment of HCV infection employing antibodies that inhibit the interaction of HCV virions with their receptor

~ 00175