Disulfide conjugated cell toxins and methods of making and using them

   
   

The invention pertains to the discovery of novel disulfide linked cell toxins which can ablate NK-1 receptor expressing cells. These toxins are used as pharmaceutical compositions for the ablation of NK1 receptor expressing cells and comprise a substance P (SP)-Pseudomonas exotoxin disulfide linked conjugate. The invention also includes methods of making and using these toxins and pharmaceutical compositions.

A invenção pertence à descoberta dos toxins ligados bissulfeto da pilha da novela que podem ablate o receptor NK-1 que expressa pilhas. Estes toxins são usados como composições pharmaceutical para o ablation do receptor NK1 que expressa pilhas e compreendem uma substância P (o bissulfeto do exotoxin dos SP)-sP)-Pseudomonas ligou o conjugate. A invenção inclui também métodos de fazer e de usar estes toxins e composições pharmaceutical.

 
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