Metalloproteinases

   
   

The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

A invenção atual relaciona-se à novela metalloproteinase-como proteínas. No detalhe, as moléculas isoladas do ácido nucleic são fornecidas que codificam o TACE-like humano e matrilysin-como proteínas. TACE-like e matrilysin-como polypeptides são fornecidos também como são vetores, as pilhas de anfitrião e os métodos recombinant para produzir o mesmo. A invenção mais adicional relaciona-se aos métodos de seleção para identificar os agonists e os antagonistas de TACE-like e matrilysin-como a atividade. São fornecidos também os métodos diagnósticos para detectar o cancer e os métodos therapeutic para o cancer e outros disorders caracterizados por um excedente ou sob a produção destes metalloproteinases.

 
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