Monocyte-specific particulate delivery vehicle

   
   

The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be phagocytized. The vector itself, or cells pretreated with the vector, are useful in all gene medicine applications. Because it is specific for monocytic cells, the inventive vector is particularly suited to vaccine applications. Due to the ability of monocytic cells to target tumors, the inventive vector also is suitable for use in anti-tumor applications, including conventional gene therapy.

El vector inventivo dirige específicamente la entrada en una célula del origen monocytic. El vector se compone de un componente del ácido nucleic, un componente lysosome de la evasión y una partícula que puede ser phagocytized. El vector sí mismo, o las células pretratadas con el vector, es útiles en todos los usos de la medicina del gene. Porque es específica para las células monocytic, el vector inventivo se satisface particularmente a los usos vaccíneos. debido a la capacidad de células monocytic a los tumores de la blanco, el vector inventivo también es conveniente para el uso en usos anti-tumor, incluyendo terapia convencional del gene.

 
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