Novel complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex

   
   

The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex. The novel complexes of hK2 and PI-6 of the present invention exist at an elevated level in prostate cancer tissues. Therefore, the hK2-PI6 complexes of the present invention may be used as a serum marker for detecting prostate cancer. They may also be used as an immunohistological marker to detect prostate cancer tissues. In accordance with the present invention, the hK2-PI6 complexes of the present invention may be detected in patient tissue samples by immunohistochemical and/or in patient fluid samples by in vitro immunoassay procedures. Diagnostic kits and diagnostic methods for detecting the existence of prostate cancer are also provided.

A invenção atual fornece um complexo da novela de hK2 e de PI-6 e métodos de usar o complexo da novela. Os complexos da novela de hK2 e de PI-6 da invenção atual existem em um nível elevated em tecidos do cancer do prostate. Conseqüentemente, os complexos hK2-PI6 da invenção atual podem ser usados como um marcador do serum detectando o cancer do prostate. Podem também ser usados como um marcador immunohistological detectar tecidos do cancer do prostate. De acordo com a invenção atual, os complexos hK2-PI6 da invenção atual podem ser detectados em amostras pacientes do tecido por immunohistochemical e/ou em amostras fluidas pacientes perto em procedimentos immunoassay de vitro. Os jogos diagnósticos e os métodos diagnósticos para detectar a existência do cancer do prostate são fornecidos também.

 
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> Method for removing amplification inhibitors from test samples

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