Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith

   
   

Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.

Des compositions pharmaceutiques qui incluent un conjugé d'drogue-oligomère d'insuline, un composant d'acide gras, et un composant de sel de bile sont décrits. La drogue d'insuline est en covalence couplée à une partie oligomère. Le composant d'acide gras et le composant de sel de bile sont présents dans un rapport de poids-à-poids de entre 1:5 et 5:1. Des méthodes de traiter une insuffisance d'insuline dans un sujet nécessitant un tel traitement employant de telles compositions pharmaceutiques sont également fournies, de même que des méthodes de fournir de telles compositions pharmaceutiques.

 
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