Avermectin aglycon synthase genes

   
   

The present invention relates to an isolated DNA which comprises a DNA sequence encoding avermectin aglycon synthase domains that corresponds to multifunctional enzyme proteins involved in the biosynthesis of a polyketide compound, or its mutants having avermectin aglycon synthase activity, particularly functional modules and submodules in the DNA sequence derived from Streptomyces avermitilis, a polypeptide or mutants thereof encoded by the DNA or the mutants, a vector containing the DNA or the mutants, a host cell transformed with the DNA, the mutants thereof, or the vector, and a method for producing avermectin.

A invenção atual relaciona-se a um DNA isolado que compreenda domínios codificando de um synthase do aglycon do avermectin da seqüência do DNA que corresponde às proteínas de enzyme multifunctional envolvidas no biosynthesis de um composto do polyketide, ou seus mutants que têm a atividade do synthase do aglycon do avermectin, particularmente os módulos e submódulos funcionais na seqüência do DNA derivada dos avermitilis dos streptomyces, um polypeptide ou mutants codificado disso pelo DNA ou os mutants, um vetor que contêm o DNA ou os mutants, uma pilha de anfitrião transformada com o DNA, os mutants disso, ou o vetor, e um método para produzir o avermectin.

 
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