Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria

   
   

The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at least 4 mg/l of aminoglycoside and thereafter maintaining the aminoglycoside at a concentration of up to 4 mg/l for at least 1 hour. Compositions comprising an antibacterial agent and an aminoglycoside for efficacious treatment of bacterial infection are also provided.

A invenção fornece um método de potentiating a atividade dos agentes anti-bacterianos que agem nas paredes de pilha bacterianas, compreendendo a etapa de administrar a um assunto um agente anti-bacteriano e um aminoglycoside para alcançar uma concentração peak ao menos de 4 mg/l do aminoglycoside e depois disso de manter o aminoglycoside em uma concentração de até 4 mg/l para ao menos 1 hora. As composições que compreendem um agente anti-bacteriano e um aminoglycoside para o tratamento efficacious da infecção bacteriana são fornecidas também.

 
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