Non-mucin type synthetic compounds or its carrier conjugated compounds

   
   

The purposes of this invention are preparation of the non-mucin type synthetic compounds-carrier conjugated compounds which are stable against enzymes, and which have the ability of specific reactivity to induce immune response for cancer and HIV. A compound of the general formula (1), ##STR1## wherein A represents OH or sialic acid and/or it's derivatives, and B represents OH or galactose and/or it's derivatives; T represents H or protecting groups of amine; M represents H or OH; X represents oxygen atom, --NH-- or S(O)z (where z is 0, 1 or 2); Q is H or oxygen atom; V represents lower alkyl or H; W is straight or branched alkylene groups from 0 to 5; Z is straight or branched alkylene groups from 1 to 5; i, m, and t is 0 or 1; non-mucin type synthetic compounds or it's carrier conjugated compounds, which have above mentioned compounds as a core structure of antigen.

As finalidades desta invenção são preparação do tipo combin-portador sintético compostos conjugated do non-mucin que são estáveis de encontro aos enzymes, e que têm a abilidade do reactivity específico de induzir a resposta imune para o cancer e o HIV. Um composto da fórmula geral (1), do ## do ## STR1 wherein A representa o OH ou o ácido sialic e/ou são derivatives, e do B representa o OH ou o galactose e/ou são derivatives; T representa H ou grupos protegendo do amine; M representa H ou OH; X representam o átomo de oxigênio, o --NH -- ou o S(O)z (onde z é 0, 1 ou 2); Q é átomo de H ou de oxigênio; V representam um alkyl mais baixo ou um H; W é grupos retos ou ramificados do alkylene de 0 a 5; Z é grupos retos ou ramificados do alkylene de 1 a 5; i, m, e t são 0 ou 1; o tipo compostos ou ele do non-mucin do synthetic é os compostos conjugated portador, que têm compostos acima mencionados como uma estrutura do núcleo do antígeno.

 
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