A method of treating ischemic reperfusion injury in a subject. The method
may include administering to the subject an effective amount of a
pharmaceutically acceptable formulation. The pharmaceutically acceptable
formulation may include a synthetic analog or derivative of a carotenoid.
The subject may be administered a carotenoid analog or derivative, either
alone or in combination with another carotenoid analog or derivative, or
co-antioxidant formulation. The carotenoid analog may include a
conjugated polyene with between 7 to 14 double bonds. The conjugated
polyene may include a cyclic ring including at least one substituent. In
some embodiments, a cyclic ring of a carotenoid analog or derivative may
include at least one substituent. The substituent may be coupled to the
cyclic ring with an ester functionality.
