The invention relates to nucleic acid molecules comprising a heat-inducible
promoter and to expression vectors and host cells containing at least one
nucleic acid molecule according to the invention. The present invention
further relates to kits and methods for producing one or more proteins
using the nucleic acid molecules according to the invention and to various
uses of the same. The object of the invention is to provide a promoter the
heat-inducible characteristic of which is as selective as possible, in
particular a promoter which is active in yeasts and which is suitable for
protein expression at high temperatures. This object is fulfilled by a
nucleic acid molecule comprising a heat-inducible promoter of a Hansenula
polymorpha gene coding for a protein with trehalose-6-phosphate-synthase
activity;
