Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine

   
   

A multicolumn selectivity inversion generator has been developed in which bismuth-213 is selectively extracted from an HCl solution of the actinium-225 parent (and its radiogenic descendents) by a primary separation column containing a separation medium containing a neutral oxygenated organophosphorus extractant. After rinsing with dilute HCl, the bismuth-213 is stripped with a buffered NaCl solution. The stripped solution is passed through a cation-exchange resin guard column that retains the actinium-225 and radium-225 contaminants while the bismuth-213 elutes. This generator method minimizes the unpredictable effects of radiation damage to the support material and permits the reliable production of bismuth-213 of high chemical and radionuclidic purity.

Um gerador multicolumn do inversion do selectivity foi desenvolvido em que bismuth-213 é extraído seletivamente de uma solução de HCl do pai actinium-225 (e de seus descendentes radiogenic) por uma coluna preliminar da separação que contem um meio da separação que contem um extractant organophosphorus oxygenated neutro. Após enxaguar com HCl diluído, o bismuth-213 é descascado com uma solução protegida do NaCl. A solução descascada é passada através de uma coluna do protetor da resina de cation-exchange que retenha os contaminadores actinium-225 e radium-225 quando o bismuth-213 elutes. Este método do gerador minimiza os efeitos impredizíveis dos danos da radiação ao material de sustentação e permite a produção de confiança de bismuth-213 do produto químico elevado e do purity radionuclidic.

 
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