Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-P-nitrobenzenesulfony lamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines

   
   

The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfony lamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfony lamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.

Присытствыющий вымысел обеспечивает новый процесс для подготовки 2S, хлоргидрата lamide 3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfony, при котором эта смесь подготовлена сразу от chloromethylalcohol. Важно, процесс вымысла настоящего момента приводит к в более высоких выходах 2S, хлоргидрате lamide 3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfony без жертвовать свою очищенность. Процессы присытствыющего вымысла можно использовать для того чтобы подготовить not only 2S, 3S-derivative, но также 2r, 3s -, 2s, 2r- и 2R, 3R-derivatives.

 
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