Plasmid-based vaccine for treating atherosclerosis

   
   

A plasmid-based vaccine is provided herein based on the combination of DNA segments coding for one or more B cell epitopes of CETP and one or more broad range helper T cell epitopes. Administration of the plasmids as a vaccine to a vertebrate subject provides an immune response to the subject's endogenous CETP and modulation of CETP activity, leading to prevention or reversal of various manifestations of heart disease. The vaccines provide an advantageous strategy for the prevention or treatment of atherosclerosis.

 
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< Modified proteins of the TGF-.beta. superfamily, including morphogenic proteins

< Transgenic plants and methods for production thereof

> Expression systems for functional nucleic acid expression

> Polyhydroxyalkanoate that comprises unit having substituted or unsubstituted (phenylmethyl) sulfanyl structure in side chain thereof and process for producing the same

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