The present invention comprises the optimization of a four zone simulated
moving bed system configured to separate a first component from a mixture
containing the first component and a second component wherein the first
component exhibits non-linear adsorption and non-negligible mass transfer
resistances. In one example, the four zone simulated moving bed is
optimized to separate Clarithromycin from a mixture containing
Clarithromycin and 6,11-O-methyl erythromycin A. The present invention
further comprises a four zone or a five zone apparatus having a first
portion and a second portion and the optimization of the four zone or five
zone apparatus to separate a first component from a mixture containing the
first component and a second component and the method of using the same.
In one example, the four zone and five zone simulated moving beds are
optimized to separate Clarithromycin from a mixture containing
Clarithromycin and 6,11-O-methyl erythromycin A. The present invention
further comprises a batch elution system configured to separate
Clarithromycin from a mixture containing Clarithromycin and 6,11-O-methyl
erythromycin A.
