Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation

   
   

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 .alpha.-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).

A invenção atual fornece composições spray-dried altamente dispersible do pó, e no detalhe, as composições secas inhaleable do pó para aerosolized a entrega aos pulmões. Os pós da invenção são produzidos pela secagem de pulverizador uma proteína do pacote de 4 alpha.-hélices sob as circunstâncias que (i) protege a proteína do aggregation e (ii) fornece as partículas apropriadas para o inhalation (isto é, demonstrando o desempenho superior do aerossol).

 
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