Detection of antibodies to gangliosides using solid-phase reactants coated with carbonyl groups

   
   

Methods of detecting antibodies to one or more ganglioside(s) of interest in a sample are disclosed which comprise using a solid-phase reactant having carbonyl groups attached thereon, and the ganglioside(s) of interest linked to the solid-phase reactant by an amide bond between an amino group of the ganglioside of interest and a carbonyl group attached to the solid-phase reactant. The methods of detecting antibodies to ganglioside(s) of interest can be used in methods of diagnosing neuropathies in an individual.

Los métodos de detectar los anticuerpos a unos o más ganglioside(s) del interés en una muestra se divulgan que abarquen con un reactivo solid-phase que hace grupos de carbonyl unir sobre eso, y el ganglioside(s) del interés son ligados al reactivo solid-phase por un enlace de la amida entre un grupo amino del ganglioside del interés y un grupo de carbonyl unido al reactivo solid-phase. Los métodos de detectar los anticuerpos al ganglioside(s) del interés se pueden utilizar en métodos de diagnosticar neuropathies en un individuo.

 
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