Alzheimer's disease secretase, APP substrates therefor, and uses therefor

   
   

The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

A invenção atual fornece o enzyme e os procedimentos enzymatic cleaving o local do cleavage do secretase do beta. da proteína do APP e os ácidos nucleic, os peptides, os vetores, as pilhas e os isolates e os assays associados da pilha. A invenção mais adicional fornece uma proteína modificada do APP e uns ácidos nucleic, uns peptides, uns vetores, umas pilhas, e uns isolates da pilha, e uns assays associados que sejam particularmente úteis para identificar o therapeutics do candidato para o tratamento ou a prevenção da doença de Alzheimer.

 
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