The present invention provides the enzyme and enzymatic procedures for
cleaving the .beta. secretase cleavage site of the APP protein and
associated nucleic acids, peptides, vectors, cells and cell isolates and
assays. The invention further provides a modified APP protein and
associated nucleic acids, peptides, vectors, cells, and cell isolates, and
assays that are particularly useful for identifying candidate therapeutics
for treatment or prevention of Alzheimer's disease.
