Modulators of peroxisome proliferator activated receptors

   
   

The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof, and methods of making, methods of using and pharmaceutical compositions having compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: ##STR1## In Structural Formula I, n is 2, 3, or 4; V is O or S; W is O, S, or SO.sub.2 ; R.sub.1 is H, a C1-C4 alkyl, phenyl or trifluoromethyl; R.sub.2 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, a cycloalkyl, or together with the phenyl to which they are bound form naphthyl or 1,2,3,4-tetrahydronaphthyl; R.sub.3 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, or a cycloalkyl; R.sub.4 are each, independently, H, a C1-C4 alkyl, an aryl, or benzyl; R.sub.5 are each, independently, H, a substituted or unsubstituted aryl or a heteroaryl, provided that at least one R.sub.5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and R.sub.6 is H, a C1-C4 alkyl, or an aminoalkyl.

A invenção atual é dirigida aos compostos representados por Estrutural Fórmula I e pharmaceutically sais aceitáveis, solvates e hydrates disso, e métodos de fazer, métodos de usar-se e de composições pharmaceutical que têm compostos representados por Estrutural Fórmula I e pharmaceutically sais aceitáveis, solvates e hydrates disso: ## do ## STR1 Na fórmula estrutural I, n é 2, 3, ou 4; V são O ou S; W é O, S, ou SO.sub.2; R.sub.1 é H, um alkyl C1-C4, phenyl ou trifluoromethyl; R.sub.2 são cada um, independentemente, H, C1-C6 um alkyl, aryl-C1-C6 um alkyl, cycloalkyl-C1-C4 um alkyl, um arilo, um cycloalkyl, ou junto com o phenyl a que são naphthyl encadernado do formulário ou 1,2,3,4-tetrahydronaphthyl; R.sub.3 são cada um, independentemente, H, um alkyl C1-C6, uns alkyl aryl-C1-C6, um alkyl cycloalkyl-C1-C4, um arilo, ou um cycloalkyl; R.sub.4 são cada um, independentemente, H, um alkyl C1-C4, um arilo, ou benzyl; R.sub.5 são cada um, independentemente, H, um arilo substituído ou unsubstituted ou um heteroaryl, contanto que ao menos um R.sub.5 é um arilo substituído ou unsubstituted ou um heteroaryl substituído ou unsubstituted; e R.sub.6 é H, um alkyl C1-C4, ou um aminoalkyl.

 
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