Process for lactonization to produce highly pure simvastatin

   
   

There is disclosed, a process for lactonization to produce highly pure simvastatin of Formula I ##STR1## which comprises lactonization of a compound of Formula II ##STR2## where Z is H or NH.sub.4 in a mixture of acetonitrile and glacial acetic acid under anhydrous conditions at a temperature of 65-70.degree. C.

    INVENTORS
    Name              Residence                      Citizenship
    Ramesh            403, Janapriya Pramila Enclave   Indian
    Dandala           Uma Nagar, Kundangagh, Begumpet
                      Hyderabad - 500 016 (India)
    Sonny             505, Vishai Towers, A Block      Indian
    Sebastian         A.S. Raju Nagar, Kukatpally,
                      Hyderabad - 500 072 (India)
    Dandala           12-5A, J.J. Nagar                Indian
    Subramanyam       Alwai, Secunderabad - 500 060
                      (India)
    Meenakshisunderam D-1, Hidden Treasure Apartments   Indian
    Sivakumaran       Near Ayyappa Swami Temple Lane
                      Somajiguda, Hyderabad - 500 082
                      (India)

On révèle, un processus pour que le lactonization produise le simvastatin fortement pur du ## du ## STR1 de la formule I qui comporte le lactonization d'un composé de ## du ## STR2 de la formule II où Z est H ou NH.sub.4 dans un mélange d'acétonitrile et d'acide acétique glaciaire dans des conditions anhydres à une température de 65-70.degree. C. INVENTEURS Citoyenneté Nommée Ramesh 403, Enclave Dandala Indien Uma Nagar, Kundangagh, Begumpet Hyderabad - 500 016 (L'Inde) Sonny 505, Vishai De Résidence De Janapriya Pramila Domine, Un Bloc Sebastian Indien A.S. Raju Nagar, Kukatpally, Hyderabad - 500 072 (L'Inde) Dandala 12-5A, J.J. Nagar Subramanyam Indien Alwai, Secunderabad - 500 060 (L'Inde) Meenakshisunderam D-1, Appartements Cachés De Trésor Sivakumaran Indien Près De Ruelle Somajiguda, Hyderabad De Temple De Swami D'Ayyappa - 500 082 (L'Inde)

 
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