Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids

   
   

Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.

È rilevata la scoperta sorpresere che i aminophospholipids, quali la fosfatidilserina ed il phosphatidylethanolamine, sono indicatori specifici, accessibili e stabili della superficie di luminal dei vasi sanguigni del tumore. La presente invenzione fornisce così le costruzioni diagnostiche e terapeutiche aminophospholipid-designate per uso nell'intervento del tumore. l'agente Anticorpo-terapeutico coniuga e le costruzioni che si legano ai aminophospholipids sono fornite specialmente, come sia metodi specificamente di trasporto degli agenti terapeutici, compreso le tossine ed i coagulanti, ai aminophospholipids stabile-espressi dei vasi sanguigni del tumore, quindi inducenti la trombosi, la necrosi e la regressione del tumore.

 
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