Substituted aza-oxindole derivatives

   
   

Substituted aza-oxindole derivatives useful as cyclin dependent kinase II inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiation therapy in a patient receiving such therapy.

Dérivés substitués d'aza-oxindole utiles en tant qu'inhibiteurs dépendants de la kinase II de cyclin, pour preventing/reducing la sévérité des effets secondaires épithéliaux de cytotoxicité (par exemple, alopécie, syndrome plantar-palmar, mucositis) induits par thérapie radiologique chemoptherapy et/ou dans un patient recevant une telle thérapie.

 
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