Method of treating prolonged critical illness and other conditions having a similar neuroendocrine pattern

A method of treating a subject suffering from a condition involving a blunted anterior pituitary hormone pattern in which Thyroid Releasing-Hormone (TRH) and Growth Hormone-Releasing Peptide (GHRP) are administered to the subject. The TRH and GHRP reactivate the blunted anterior pituitary hormone release mechanism of the subject. Treatable conditions include critical illness, non-coping mental and physical stress and frail elderly syndrome.