Antibodies to chemokine receptor 88C

   
   

The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.

A invenção atual fornece os polynucleotides que codificam os receptors 88-2B ou 88C do chemokine e materiais e métodos para a produção recombinant destes dois receptors do chemokine. São fornecidos também os assays que utilizam os polynucleotides que facilitam a identificação dos ligands e dos moduladores dos receptors do chemokine. Os fragmentos, os ligands, os moduladores, e os antibodies do receptor são úteis na deteção e no tratamento dos estados da doença associados com os receptors do chemokine tais como o atherosclerosis, o arthritis rheumatoid, a supressão do crescimento do tumor, o asthma, a infecção viral, os AIDS, e outras circunstâncias inflammatory.

 
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