Process for lactonization to produce simvastatin

   
   

There is disclosed a process for the manufacture of simvastatin of Formula I ##STR1## which comprises heating a compound, namely acid or ammonium salt of compound of Formula II, ##STR2## where Z is H or NH.sub.4 in an organic solvent at a temperature of 130-140.degree. C.

    Name              Residence                      Citizenship
    Ramesh            403, Janapriya Pramila Enclave India
    Dandala           Uma Nagar, Kundanbagh, Begumpet
                      Hyderabad - 500 016 (India)
    Sonny             505, Vishal Towers, A Block    India
    Sebastian         A.S. Raju Nagar, Kukatpally,
                      Hyderabad - 500 072 (India)
    Sanapureddy       4/134, Pakeerpalli,            India
    Jagan Mohan       Sankarapuram (post)
    Reddy             Cuddapah - 516 002 (India)
    Meenakshisunderam D-1, Hidden Treasure Apartments India
    Sivakumaran       Near Ayyappa Swami Temple Lane
                      Somajiguda, Hyderabad - 500 082
                      (India)

 
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