The invention features novel osteoregulin polypeptides, nucleic acid
sequences which encode the polypeptides, vectors, antibodies, hosts which
express heterologous osteoregulins, and animal cells and mammals with a
targeted disruption of an osteoregulin gene. These osteoregulins play a
role in regulating bone homeostasis, adiposity, and the calcification of
atherosclerotic plaques. Accordingly, the invention also features
screening assays to identify modulators of osteoregulin activity as well
as methods of treating mammals for diseases or disorders associated with
osteoregulin activity.
A invenção caracteriza polypeptides do osteoregulin da novela, as seqüências que codificam os polypeptides, vetores, antibodies, os anfitriões do ácido nucleic que osteoregulins heterologous expressos, e as pilhas e os mamíferos animais com um rompimento alvejado de um gene do osteoregulin. Estes osteoregulins jogam um papel na homeostase regulando do osso, no adiposity, e no calcification de chapas atherosclerotic. Conformemente, a invenção caracteriza também assays da seleção para identificar moduladores da atividade do osteoregulin as.well.as métodos de tratar mamíferos para as doenças ou os disorders associadas com a atividade do osteoregulin.
