Methods for treating diabetes via administration of controlled release metformin

   
   

A method for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as metformin, on a once-a-day basis. The dosage form provides a mean time to maximum plasma concentration (T.sub.max) of the drug which occurs at a 5.5 to 7.5 hours after oral administration on a once-a-day basis to human patients. Preferably, the dose of drug is administered at dinnertime to a patient in the fed state.

Метод для обрабатывать пациентов имея нон-инсулин-zavisimoe mellitus мочеизнурения (NIDDM) путем administering форма дозировки controlled отпуска устно твердая содержа предпочтительн снадобье biguanide such as metformin, на основание как только-$$$-DN4. Форма дозировки снабубежит среднее время максимальная концентрация плазмы (T.sub.max) снадобья происходит на от 5.5 до 7.5 часах после администрирования на основание как только-$$$-DN4 к людским пациентам. Предпочтительн, доза снадобья administered на dinnertime к пациенту в поданном положении.

 
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