DNA and protein from Dirofilaria immitis

   
   

In accordance with the present invention, a 31-33 kDa glycoprotein of D. immitis (DiT33) is provided which represents another member of the family of putative pepsin inhibitors. Other known members include Ov33 (a.k.a. Ov33.3, Oc3.6, OvD 5B), Bm33 and Av33. These filarial molecules possess significant homology to the known pepsin inhibitor (Aspi3) of A. suum. Using DiT33 or Ov33, in the form of a recombinant fusion or non-fusion protein, antibody responses to DiT33 may be monitored and used in immunodiagnosis of heartworm infection in mammals. Antibodies reactive with the DiT33 or Ov33 may also be used to detect DiT33 antigen as a means of immunodiagnosis of heartworm infection in mammals.

De acordo com a invenção atual, um glycoprotein do kDa 31-33 de D. o immitis (DiT33) é fornecido que representa um outro membro da família de inibidores putative do pepsin. Outros membros conhecidos incluem Ov33 (a.k.a. Ov33.3, Oc3.6, OvD 5B), Bm33 e Av33. Estas moléculas filarial possuem o homology significativo ao inibidor sabido do pepsin (Aspi3) do suum do A.. Usando DiT33 ou Ov33, no formulário de uma proteína recombinant da fusão ou da non-fusão, as respostas do antibody a DiT33 podem ser monitoradas e usado no immunodiagnosis da infecção do heartworm nos mamíferos. Os antibodies reactive com o DiT33 ou o Ov33 podem também ser usados detectar o antígeno DiT33 como meios do immunodiagnosis da infecção do heartworm nos mamíferos.

 
Web www.patentalert.com

< Method for manufacturing a shape body containing a starch, a homogenised mass containing starch and a device for manufacturing a soft capsule

< Substance that stop any kind of bleeding within one second for medical, surgical, postsurgical and dental uses

> Serum-derived factor inducing cell differentiation and medical uses thereof

> G protein-coupled receptor up-regulated in prostate cancer and uses thereof

~ 00131